Two-three day treatment provides clinically relevant, sustained clearance of AK after 12 months An analysis of long-term clearance rates of actinic keratosis (AK) lesions after treatment with ingenol mebutate (Picato(R)) gel is today published in the Journal of the American Medical Association (JAMA) Dermatology,[1] formerly known as the Archives of Dermatology. (Photo: http://photos.prnewswire.com/prnh/20130221/595427 ) Previously, the pooled results of the four phase III trials of ingenol